The BCL2 antibody from Wuhan Fine Biotech Co., Ltd. is a Mouse Monoclonal antibody to BCL2, and BCL2 apoptosis regulator. This antibody recognizes Homo Sapiens, and Human antigen. The BCL2 antibody has been validated for the following applications: EIA, Immunoassay, Precipitation, ELISA, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor(APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785)